Cancer jab eradicates tumors entirely in some trial patients

Doctors have welcomed ground-breaking trial results that show a triple-action cancer jab can eradicate entire tumors in patients.

In an international trial spanning 11 countries, including the UK, the injection was offered to patients whose cancer had spread or come back and whose disease had failed to respond to other treatments.

The jab, called amivantamab, shrank the tumors of more than a third of patients, with dramatic changes seen within weeks. In 15 of them, doctors found the drug had melted away their tumors altogether.

Striking level of benefit

"These are unprecedentedly strong responses in patients whose disease has become resistant to both chemotherapy and immunotherapy," said Kevin Harrington, professor in biological cancer therapies at the Institute of Cancer Research, London (ICR). "This is a group of patients for whom treatment options are extremely limited, so seeing this level of benefit is very striking."

Harrington, also a consultant oncologist at London's Royal Marsden NHS foundation trust, added: "This treatment has the potential to benefit many thousands of patients each year."

The results were presented on Sunday in Chicago at the world's largest cancer conference, the annual meeting of the American Society of Clinical Oncology (Asco).

In the trial, 102 patients with head and neck cancer, the world's sixth most common cancer, were given the jab. Tumors shrank or disappeared completely in 43 patients, including 28 whose tumors shrank significantly and 15 who saw them eradicated entirely.

Researchers said the injection had also shown similar results in patients with lung cancer. 

Three-pronged attack

Amivantamab, developed by Johnson & Johnson, is now being evaluated in about 60 clinical trials, primarily for lung cancer, but also for colorectal, brain and gastric cancers.

The smart jab targets cancer in three ways. It blocks both epidermal growth factor receptors (EGFR), a protein that helps tumors grow, and MET, a pathway that cancer cells often use to escape treatment. It also helps activate the immune system to attack the tumor.

One of the first patients to benefit was Carl Walsh, 56, who was diagnosed with tongue cancer in May 2024 and joined the OrigAMI-4 trial at the Royal Marsden in July 2025.

"I was initially treated with both chemotherapy and immunotherapy, which unfortunately were not successful," he said. "At that point, I was recommended for the OrigAMI-4 trial. I’m now on my 17th cycle of treatment and I'm very pleased with the progress so far."

Unlike many cancer treatments, amivantamab is given as a tiny jab under the skin rather than via an intravenous drip, making treatment quicker and more convenient for patients and much easier to deliver in outpatient clinics.

'Feel able to live a normal life'

Most side effects of the treatment, given once every three weeks, were mild to moderate, with fewer than one in 10 patients forced to stop their treatment.

"I now feel able to live a normal life. Before starting the trial, I struggled to speak properly and found eating difficult because of the swelling and pain," said Walsh.

"Since beginning treatment, the swelling has reduced significantly, and my pain levels have improved considerably. I'm also no longer experiencing the same life-impacting side effects that I had during chemotherapy," he explained.

He also lost quite a bit of weight.

"After only two cycles of the treatment my diet started to return to normal and I was eating a full diet after six months," said Walsh. "The thing I enjoyed most was the first big steak. My speech is completely back to normal and at work I speak regularly on headsets without problems."

Encouraging survival outcomes

Researchers also highlighted that the trial focused on people with head and neck cancers that did not include those with human papillomavirus (HPV) positive oropharyngeal squamous cell carcinoma. 

They say this is particularly significant, since head and neck cancers not caused by HPV are usually harder to treat, making progress in this group hugely important.

Patients receiving amivantamab lived for a median of 12.5 months overall after starting treatment, despite having a form of cancer with very poor outcomes, once standard treatments stop working.

"This study demonstrates how the development of new treatments through rigorous cancer research may lead to meaningful advances, even for patients with very limited treatment options," said Kristian Helin, the chief executive of the ICR.

"Achieving this level of tumor response and encouraging survival outcomes in such a challenging‑to‑treat group represents a significant step forward."