The report analyzes existing studies conducted from 1990 to 2021, finding that in high-income countries, 17.8 percent of adults were affected by infertility during their lifetime.
That compares to 16.5 percent in low- and middle-income countries.
Tedros said the report, the first of its kind in a decade, highlighted "an important truth: Infertility does not discriminate."
Infertility is a disease of the male or female reproductive system characterized by the failure to achieve a pregnancy after 12 months or more of regular unprotected sexual intercourse.
The WHO has designated the issue a "major health challenge globally."
However, it also stressed the difficulty of comparing the situation in various regions due to a lack of data, warning that there were significant variations in the data gathered.
"Infertility affects millions," said Tedros, adding that "even still, it remains understudied, and solutions underfunded, and inaccessible to many, as the result of high costs, social stigma and limited availability."
Pascale Allotey, head of the WHO's Sexual and Reproductive Health and Research division, also raised the stigma associated with infertility and the inequity in access to treatment.
"Procreation comes with a significant societal pressure," she said, pointing out that in many countries "pregnancy remains critical to the perception of womanhood and... of a couple."
"Failure is often met with stigma," she added adding that people with infertility often suffered anxiety and depression.
There is also "an increased risk of intimate partner violence associated with infertility, as relationships are tested," she warned.
The WHO is calling on countries to include infertility treatment as part of their reproductive health policies, services and financing in a bid to promote "safe, effective, and affordable ways to attain parenthood."